ncRNA name | LSD1 siRNA |
ncRNA Category | siRNA |
Disease name | diabetic retinopathy (DR) |
Species | Bos taurus |
Tissues/Cell_line | bovine retinal endothelial cells (BRECs) |
Methods | siRNA transfection, semi-qPCR, qRT-PCR, Western blot, ELISA |
Expression pattern | associated |
Functional description | LSD1 siRNA ameliorated the glucose-induced decrease in H3K9me2 and increase in p65 at the MMP-9 promoter, and prevented MMP-9 activation, mitochondrial damage, and cell apoptosis. |
PubMed ID | 23423566 |
Year | 2013 |
Title | Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. |
Drug-related ncRNA | NO |
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